What are Thrombotic Microangiopathies Involving the Kidney?

Thrombotic Microangiopathies Involving the Kidney
Kidney biopsy findings: (a) transplant glomerulitis with infiltrating mononuclear inflammatory cells within the capillary loops, second biopsy (PAS, magnification ×200); (b) glomerulus with a thrombus involving the vascular pole, second biopsy (Jones, magnification ×200); (c) glomeruli showing persistent transplant glomerulitis and thrombotic microangiopathy, fourth biopsy (PAS, magnification ×100); (d) immunofluorescence microscopy showing C4d mesangial deposition without peritubular capillary staining (magnification ×100). Eculizumab for the Treatment of Severe Antibody-Mediated Rejection: A Case Report and Review of the Literature: Tran D, Boucher A, Collette S, Payette A, Royal V, Senécal L - Case reports in transplantation (2016). Not altered. CC.

Thrombotic microangiopathies involving the kidney is the thrombosis in renal capillaries and arterioles

What is the Pathology of Thrombotic Microangiopathies Involving the Kidney?

The pathology of thrombotic microangiopathies involving the kidney is: 

-Etiology: The cause of thrombotic microangiopathies involving the kidney is conditions such as hemolytic uremic syndrome, disseminated intravascular coagulation, and malignant hypertension.

-Genes involved: Unknown.  

-Pathogenesis: The sequence of events that lead to thrombotic microangiopathies involving the kidney follows endothelial injury and activation and platelet aggregation causing vascular obstruction and vasoconstriction leading to ischemia.

-Morphology: The morphology associated with thrombotic microangiopathies involving the kidney shows patchy or diffuse renal cortical necrosis.

-Histology: The histology associated with thrombotic microangiopathies involving the kidney shows glomeruli thickening and splitting of capillary walls.

How do Thrombotic Microangiopathies Involve the Kidney Present? 

Patients with thrombotic microangiopathies involving the kidney typically have no gender preference reported present at the age range of old age. The symptoms, features, and clinical findings associated with thrombotic microangiopathies involving the kidney include blood stain urine, UTI, high blood pressure, decreased urine, and fever.

How are Thrombotic Microangiopathies Involving the Kidney Diagnosed? 

Thrombotic microangiopathies involving the kidney are diagnosed through laboratory studies such as kidney function test, urinalysis. Imaging studies such as ultrasonography, radionuclide scanning, spiral CT angiography. 

How are Thrombotic Microangiopathies Involving the Kidney Treated? 

Thrombotic microangiopathies involving the kidney are treated by symptomatic management, and managing the underlying cause.

What is the Prognosis of Thrombotic Microangiopathies Involving the Kidney?

The prognosis of thrombotic microangiopathies involving the kidney is good. With proper management, the patient recovers in weeks.

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Last updated on May 24, 2022