Transcription factors are proteins that bind to the upstream regulatory elements of genes in the promoter and enhancer regions of DNA and stimulate or inhibit transcription. The DNA binding domain is involved with transcription because it gives the ability to bind to specific sequences of DNA called enhancer or promoter sequences.
What are Transcription Factors?
Transcription factor expression in the ventrolateral lineage interneurons (vILNs). Third instar (A-C) larval and (D-F) adult brains with vlLNs labelled with Gal4-OK371, UAS-mCD8::GFP. (A,D) Antennal lobe (white dots) and neurons (yellow dots) in the lineage. (B, C, E, F) Single confocal sections through the somata from (B,C) larval and (E,F) adult brains labelled with antibodies against (B,E) dLim1 and (C,F) Cut. Labelling is more abundant in developing than in adult brains. (B, C, E and F) Cell bodies co-labelled with the corresponding transcription factor (yellow arrowheads). D = dorsal, L = lateral. Scale bar = 10 μm. Identification and analysis of a glutamatergic local interneuron lineage in the adult Drosophila olfactory system. Das A, Chiang A, Davla S, Priya R, Reichert H, Vijayraghavan K, Rodrigues V - Neural systems & circuits (2011). Not Altered. CC.
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