Role of EVs in pathogenesis of preeclampsia. Maternal risk factors and placental abnormalities cause systemic maternal cell activation resulting in release of EVs. Endothelial-, leukocyte-, and platelet-derived EVs give rise to vascular dysfunction, immune modulation, and increased thrombotic propensity. These processes collectively contribute to progression of pathogenesis of preeclampsia. Preeclampsia and Extracellular Vesicles. Current Hypertension Reports. Not Altered. CC.