What is a Well Differentiated Liposarcoma?

Well Differentiated Liposarcoma
Well Differentiated Liposarcoma. Histological diagnosis with hematoxylin-eosin showing malignant fibrous histiocytoma-like findings mixed with those for well-differentiated liposarcoma, leading to the diagnosis of dedifferentiated liposarcoma. a Well-differentiated liposarcoma components and malignant fibrous histiocytoma-like findings with a distinct border. b Malignant fibrous histiocytoma-like findings. c Well-differentiated liposarcoma components. A Retroperitoneal Dedifferentiated Liposarcoma Producing Granulocyte Colony-Stimulating Factor Accompanied by Spontaneous Rupture: PET/CT Imaging of a G-CSF-Producing Tumor. Hara R - Case reports in oncology (2011). Not Altered. CC.

Well, differentiated liposarcoma is the most common subtype of liposarcoma. 

What is the Pathology of Well-differentiated Liposarcoma? 

The pathology of well-differentiated liposarcoma is: 

-Etiology: The cause of well-differentiated liposarcoma is extensive chromosomal aberrations. 

-Genes involved: MDM2, CDK4, HMGA2. 

-Pathogenesis: The sequence of events that lead to well-differentiated liposarcoma are having a diagnostic giant marker and ring chromosome, which affects uncontrolled cell proliferation.

-Histology: The histology associated with well-differentiated liposarcoma shows atypical stromal cells and lipoblasts in the context of mature fat. 

How does Well-Differentiated Liposarcoma Present? 

Patients with well-differentiated liposarcoma typically affect both males and females in the 6th decade of life. The symptoms, features, and clinical findings associated with well-differentiated liposarcoma include a painless mass present most often in the retroperitoneum or the limbs, urinary or bowel obstruction.

How is Well-Differentiated Liposarcoma Diagnosed? 

Well-differentiated liposarcoma is diagnosed by CT scan and MRI. 

How is Well-Differentiated Liposarcoma Treated? 

Well-differentiated liposarcoma is treated mainly through tumor excision. 

What is the Prognosis of Well-Differentiated Liposarcoma? 

The prognosis of well-differentiated liposarcoma is good with complete tumor excision. 

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Last updated on May 19, 2022