What is Acetaminophen Injury?

Acetaminophen Injury
Protective role of autophagy in APAP-induced hepatotoxicity. APAP is metabolized in hepatocytes to generate NAPQI, which depletes GSH stores and induces mitochondrial damage by generating protein adducts, leading to hepatic necrosis. Autophagy is induced as a defense mechanism and promotes cell survival by removing damaged mitochondria and decreasing oxidative stress. Pharmacological activation of autophagy promotes cell survival while its inhibition favors cell death, APAP: acetaminophen; NAPQI: N-acetyl-p-benzoquinone imine; GSH: glutathione; mTOR: mammalian target of rapamycin. Liver autophagy in anorexia nervosa and acute liver injury. Kheloufi M, Boulanger CM, Durand F, Rautou PE - BioMed research international (2014). Not Altered. CC.

Acetaminophen injury is the injury caused by taking the drug acetaminophen. 

What is the Pathology of Acetaminophen Injury?

The pathology of acetaminophen injury is:

-Etiology: The cause of acetaminophen injury is drug overdose.

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to acetaminophen injury include gastric emptying with increased elimination of half-life.

-Morphology: The morphology associated with acetaminophen injury shows NAPQI.

-Histology: The histology associated with acetaminophen injury shows cytolysis and the presence of centrilobular necrosis.

How does Acetaminophen Injury Present?

Patients with acetaminophen injury typically affect males and females present at the age range of 35-55. The symptoms, features, and clinical findings associated with acetaminophen injury include yellowing of skin or eyes, pain in abdomen, nausea, and vomiting, loss of appetite, fatigue, excessive sweating, dark urine and stools, and pale skin color.

How is Acetaminophen Injury Diagnosed?

Acetaminophen injury is diagnosed using a blood test.

How is Acetaminophen Injury Treated?

Acetaminophen injury is treated with intravenous fluids

What is the Prognosis of Acetaminophen Injury?

The prognosis of acetaminophen injury is fair if treated properly. 

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Last updated on May 26, 2022