What is Acute Proliferative Glomerulonephritis?

Acute Proliferative Glomerulonephritis
(A) Five enlarged glomeruli in IgA-dominant acute post-streptococcal glomerulonephritis showing diffuse global endocapillary hypercellularity (hematoxylin and eosin [HE] staining). (B) An enlarged glomerulus with global closure of the capillary lumina caused by endogeneous predominantly mesangial cell proliferation and infiltrating blood-borne monocytes and polymorphonuclear leukocytes (HE staining). (C) Numerous brown stained CD68-positive monocytes infiltrating the enlarged hypercellular glomerular tuft (anti-CD68 monoclonal antibody, clone KP-1, immunohistochemistry using ultraView DAB detection kit, Ventana Medical Systems, Tuscon, AZ, USA). (D-F) Immunofluorescence microscopy showing granular mesangial and glomerular capillary wall immune deposits with a “starry-sky” pattern of IgA dominance (D), less intensive IgG (E), and prominent C3 (F). (G) Part of a glomerular lobule showing a pronounced endocapillary hypercellularity caused by proliferating (note one mitotic figure) predominant mesangial cells, surrounded by a mesangial matrix with discrete dense deposits, as well as by infiltrating leukocytes (electron micrograph). (H) Discrete electron-dense subendothelial and subepithelial deposits detected using high magnification (electron micrograph). (I) A solitary hump-shaped electron-dense deposit on the outer aspect of the glomerular basement membrane (electron micrograph). IgA-dominant acute post-streptococcal glomerulonephritis with concomitant rheumatic fever successfully treated with steroids: a case report: Rus RR, Toplak N, Vizjak A, Mraz J, Ferluga D - Croatian medical journal (2015). Not altered. CC.

Acute proliferative glomerulonephritis is a disease of the glomeruli that is caused by bacterial infection.

What is the Pathology of Acute Proliferative Glomerulonephritis?

The pathology of acute proliferative glomerulonephritis is the scientific study of the disease of the glomeruli caused by bacterial infection, especially the streptococcus type.

-Etiology: The cause of acute proliferative glomerulonephritis is streptococcus bacteria.

-Genes involved: Unknown. 

-Pathogenesis: The sequence of events that lead to acute proliferative glomerulonephritis, the infection affects the blood vessels leading to inflammation of the glomeruli rendering the renal organ ineffective if the process of urine filtering.

-Morphology: Not applicable. 

-Histology: The histology associated with acute proliferative glomerulonephritis shows diffuse, focal and mesangial patterns.

How does Acute Proliferative Glomerulonephritis Present? 

Patients with acute proliferative glomerulonephritis typically are males present at the the age range of 5-15 years. The symptoms, features, and clinical findings associated with acute proliferative glomerulonephritis include hematuria, oliguria, edema, hypertension, fever, headache.

How is Acute Proliferative Glomerulonephritis Diagnosed? 

Acute proliferative glomerulonephritis is diagnosed with kidney biopsy, blood tests, physical examination.

How is Acute Proliferative Glomerulonephritis Treated? 

Acute proliferative glomerulonephritis is treated by blood pressure control, low sodium diet, loop diuretics, beta blockers.

What is the Prognosis of Acute Proliferative Glomerulonephritis?

The prognosis of acute proliferative glomerulonephritis is good since once the symptoms are managed the disease resolves.

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Last updated on May 24, 2022