What is Adenocarcinoma of the Bladder?

Adenocarcinoma of the Bladder
Adenocarcinoma of the Bladder. a: Primary bladder adenocarcinoma, enteric type. Moderately differentiated malignant glands are seen with dirty luminal necrosis. Elongated, enlarged and hyperchromatic nuclei with prominent stratification line the malignant glands. (Hematoxylin & eosin, x100). b: Primary bladder adenocarcinoma, mucinous type. Scattered small groups of tumor cells with intracytoplasmic mucin are seen in a background of abundant mucinous material (Hematoxylin & eosin, x200). c: Primary bladder adenocarcinoma, signet ring cell type: Tumor comprised of diffuse sheets of signet ring cells infiltrating the bladder wall (Hematoxylin & eosin, x200). d: Cystitis cystica involving the surface urothelium with underlying invasive primary bladder adenocarcinoma (Hematoxylin & eosin, x100). e: Extensive cystitis glandularis, intestinal type seen adjacent to a focus of invasive primary bladder adenocarcinoma (not seen in this image) (Hematoxylin & eosin, x40). f: Metastatic colorectal adenocarcinoma. Moderately differentiated, infiltrating malignant glands with morphological features similar to primary bladder adenocarcinoma see in a (Hematoxylin & eosin, x100). Primary bladder adenocarcinoma versus metastatic colorectal adenocarcinoma: a persisting diagnostic challenge. Roy S, Smith MA, Cieply KM, Acquafondata MB, Parwani AV - Diagnostic pathology (2012). Not altered. CC.

Adenocarcinoma of the bladder is carcinoma derived from the urothelium and showing pure glandular differentiation, not including urachal adenocarcinoma or urothelial carcinoma with glandular differentiation.

What is the Pathology of Adenocarcinoma of the Bladder?

The pathology of adenocarcinoma of the bladder is:

-Etiology: The causes of adenocarcinoma of the bladder is the progression of extensive intestinal metaplasia (cystitis glandularis) or villous adenoma.

-Genes involved: TP53, KRAS, PIK3CA, CTNNB1, APC, and the promoter of TERT.

-Pathogenesis: The sequence of events that lead to adenocarcinoma of the bladder is the metaplasia of the urinary bladder induced by chronic irritation or infection that can lead to adenocarcinoma. 

-Morphology: The morphology associated with adenocarcinoma of the bladder shows 67% are solitary lesions (while urothelial carcinoma tends to be multifocal), tumor surface may be covered by gelatinous material, papillary, nodular, flat, or ulcerated.

-Histology: The histology associated with adenocarcinoma of the bladder shows nests of neoplastic cells floating in abundant extravasated mucin.

How does Adenocarcinoma of the Bladder Present?

Patients with adenocarcinoma of the bladder typically affect males more than females at 68 years of age. The symptoms, features, and clinical findings associated with adenocarcinoma of the bladder include hematuria, rarely with mucusuria, dysuria. Patients are older and mucusuria is more common than in urachal adenocarcinoma.

How is Adenocarcinoma of the Bladder Diagnosed?

Adenocarcinoma of the bladder is diagnosed by urine cytology, CT, MRI, and biopsy.

How is Adenocarcinoma of the Bladder Treated?

Adenocarcinoma of the bladder is treated by radical cystectomy and pelvic lymph node dissection.

What is the Prognosis of Adenocarcinoma of the Bladder?

The prognosis of adenocarcinoma of the bladder variable.

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Last updated on May 16, 2022