What is Adenoid Cystic Carcinoma?

Adenoid Cystic Carcinoma
Adenoid Cystic Carcinoma. Histology of the brain metastasis biopsy specimen. (A) Hematoxylin and eosine stain with magnification x 200: adenoid cystic carcinoma cells (purple) adjacent to normal brain tissue (pink) at the upper left. (B) Hematoxylin and eosine stain with magnification x 400: adenoid cystic carcinoma cells (purple) arranged in a typical cribriform pattern, forming columns around gland-like spaces. (C) Immunohistochemistry with anti-cytokeratin 7 antibodies showing a typical positive stain for adenoid cystic carcinoma cells. Brain and lung metastasis of Bartholin's gland adenoid cystic carcinoma: a case report. Ramanah R, Allam-Ndoul E, Baeza C, Riethmuller D - Journal of medical case reports (2013). Not Altered. CC.

Adenoid cystic carcinoma is a cancer of the salivary glands. 

What is the Pathology of Adenoid Cystic Carcinoma?

The pathology of adenoid cystic carcinoma is:

-Etiology: The cause of adenoid cystic carcinoma is unknown. 

-Genes involved: MYB, MYBL1 or NFIB gene.

-Pathogenesis: The sequence of events that lead to adenoid cystic carcinoma is malignant glandular tissue. 

-Histology: The histology associated with adenoid cystic carcinoma shows malignant ductal and myoepithelial cells. There is typically a cribriform pattern. 

How does Adenoid Cystic Carcinoma Present?

Patients with adenoid cystic carcinoma are typically older. The symptoms, features, and clinical findings associated with adenoid cystic carcinoma include a firm growing mass. 

How is Adenoid Cystic Carcinoma Diagnosed?

Adenoid cystic carcinoma is diagnosed by physical exam, fine needle aspiration, and biopsy. 

How is Adenoid Cystic Carcinoma Treated?

Adenoid cystic carcinoma is treated by complete surgical resection. Radiation and chemotherapy may also be needed. 

What is the Prognosis of Adenoid Cystic Carcinoma?

The prognosis of adenoid cystic carcinoma is poor, with a 5 year overall survival rate of 80%.

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Last updated on May 22, 2022