What is Age Related Macular Degeneration?

Age Related Macular Degeneration
Retinal transplantation. (A) H&E staining of a photoreceptor sheet isolated from pig retina. Photoreceptor sheets can readily be isolated via vibratome sectioning and prepared for subretinal transplantation. Resulting sheets are highly organized with proper retinal structure including photoreceptor inner- and outer-segments. (B and C) Immunhistochemical analysis of human maculas with retinal degeneration (B, Best disease and C, age-related macular degeneration) with antibodies targeted against the gliosis marker GFAP (B), the vascular stain UEA1 (C) and the lymphocyte antigen CD45 (C). Degeneration of the outer nuclear layer results in glial cell activation, outer retinal scar formation and infiltration of CD45 positive immune cells. ONL, outer nuclear layer; IS, photoreceptor cell inner segments; OS, photoreceptor cell outer segments.Stem cells for investigation and treatment of inherited retinal disease. Tucker BA, Mullins RF, Stone EM - Human molecular genetics (2014). Not Altered. CC.

Age related macular degeneration is the loss of central vision induced by the degeneration of the macular of the retina manifesting after age 50. 

The pathology of age related macular degeneration is degeneration involving the retinal photoreceptors, pigment epithelium and Bruch’s membrane.

Age related macular degeneration presents with blurry vision, distorted vision, partial vision loss, and neovascularization.

Age related macular degeneration is diagnosed by Amsler grid test, pupillary dilation test, optical coherence tomography, and fluorescein angiography.

Age related macular degeneration is treated with anti-VEGF medications, vitamin supplementation, and laser therapy.

The prognosis of age related macular degeneration can last for years or life-long.

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Last updated on May 23, 2022