What is an Ameloblastic Carcinoma?

Ameloblastic Carcinoma
(A) Ameloblastic carcinoma with area of necrosis. (B) Ameloblastic carcinoma with tumor cells exhibiting crowding, nuclear pleomorphism, and mitotic activity.Ameloblastic Carcinoma. Gunaratne DA, Coleman HG, Lim L, Morgan GJ - The American journal of case reports (2015). Not Altered. CC.

Ameloblastic carcinoma is a rare malignant (cancerous) tumor that normally begins in the bones of the jaw.

What is the Pathology of Ameloblastic Carcinoma?

The pathology of ameloblastic carcinoma is: 

-Etiology: The cause of ameloblastic carcinoma is de novo. 

-Genes involved: p53 gene.

-Pathogenesis: The sequence of events that lead to ameloblastic carcinoma is little to unknown however, malignant transformation of ameloblastomas may occur spontaneously or following chemotherapy or adjuvant radiotherapy.

-Histology: The histology associated with ameloblastic carcinoma shows peripheral palisading, reverse polarization, stellate reticulum.

How does Ameloblastic Carcinoma Present?

Patients with ameloblastic carcinoma typically affect males and females present in the age range of 40-50 years. The symptoms, features, and clinical findings associated with ameloblastic carcinoma include jaw pain and swelling.

How is Ameloblastic Carcinoma Diagnosed?

Ameloblastic Carcinoma  is diagnosed by clinical, radiologic, and pathologic correlation

How is Ameloblastic Carcinoma Treated?

Ameloblastic Carcinoma is treated by composite surgical resection, with adjuvant radiation and chemotherapy as appropriate

What is the Prognosis of Ameloblastic Carcinoma?

The prognosis of ameloblastic carcinoma is poor.