What is an Ameloblastic Fibrosarcoma?

Ameloblastic Fibrosarcoma
(a) Biphasic tumor composed of islands of benign odontogenic epithelium and an abundant malignant mesenchymal component. H&E stain, ×50. (b) The malignant mesenchymal component consists of plump and spindle stromal cells which show mild to moderate cytologic atypia and numerous mitotic figures arranged in storiform and herringbone fashion. H&E stain, ×100.Ameloblastic fibrosarcoma of the mandible: a case report and brief review of the literature. Loya-Solis A, González-Colunga KJ, Pérez-Rodríguez CM, Ramírez-Ochoa NS, Ceceñas-Falcón L, Barboza-Quintana O - Case reports in pathology (2015). Not ALtered. CC.

Ameloblastic fibrosarcoma is an uncommon odontogenic tumor composed of a benign epithelial component and a malignant ectomesenchymal component. 

What is the Pathology of Ameloblastic Fibrosarcoma?

The pathology of ameloblastic fibrosarcoma is: 

-Etiology: The cause of ameloblastic fibrosarcoma is de novo tumors tend to occur in younger patients

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to ameloblastic fibrosarcoma; they are derived from epithelial, ectomesenchymal, and mesenchymal elements of the tooth-forming apparatus.

-Histology: The histology associated with ameloblastic fibrosarcoma shows biphasic with benign epithelium and malignant stroma.

How does Ameloblastic Fibrosarcoma Present?

Patients with Ameloblastic Fibrosarcoma typically affect males present in the age range of 30-50 years. The symptoms, features, and clinical findings associated with ameloblastic fibrosarcoma include  painful but occasionally painless facial mass with accompanying paresthesia or dysesthesia.

How is Ameloblastic Fibrosarcoma Diagnosed?

Ameloblastic fibrosarcoma is diagnosed dependent on clinical, radiologic, and pathologic correlation.

How is Ameloblastic Fibrosarcoma Treated?

Ameloblastic fibrosarcoma is treated by surgical resection and radiotherapy. 

What is the Prognosis of Ameloblastic Fibrosarcoma?

The prognosis of ameloblastic fibrosarcoma is good.