What is Atelectasis?

Atelectasis
Histological andex vivoimages. (A) Histological images (50×) of the atelectasis (AT) and peri-atelectasis (PeriAT) regions are exhibited. Note the alveolar hyperinflation of the surrounding alveoli. (B)Ex vivo image of the lungs exhibiting the AT, PeriAT, and the control regions of interest. (C) Histological image of the contralateral lung (control region) of the same animal is exhibited. Note the difference in surface area of alveoli when compared with the PeriAT region. Non-lobar atelectasis generates inflammation and structural alveolar injury in the surrounding healthy tissue during mechanical ventilation. Retamal J, Bergamini BC, Carvalho AR, Bozza FA, Borzone G, Borges JB, Larsson A, Hedenstierna G, Bugedo G, Bruhn A - Critical care (London, England) (2014). Not Altered. CC.

Atelectasis is the fractional or total complete collapse of the lung or a specific portion of the lung. Incomplete expansion of the lungs (Neonatal Atelectasis).

What is the Pathology of Atelectasis?

The pathology of atelectasis is: Incomplete expansion of the lungs or partial/total Collapse collapse of the lungs leading to impaired gaseous exchange.

-Etiology: The cause of atelectasis is, impaired surfactant production, bronchial impediment by foreign bodies, growths, plugs of sputum, or endobronchial tumors.

-Genes involved: surfactant protein A (SPA1, SPA2).

-Pathogenesis: The sequence of events that lead to atelectasis is collapsed alveoli. 

-Histology: The histology associated with atelectasis shows collapsed alveoli.

How does Atelectasis Present?

Patients with atelectasis typically have no gender predilection, present at age range of 60 years. The symptoms, features, and clinical findings associated with atelectasis include chest pain, abrupt dyspnea, and cyanosis, tachycardia hypotension, shock and fever.

How is Atelectasis Diagnosed?

Atelectasis is diagnosed through laboratory studies, ABGs determine hypoxemia. Imaging studies, CT scans, and chest radiology check for lobar collapse. Bronchoscopy assesses bronchial obstruction.

How is Atelectasis Treated?

Atelectasis is treated through medical care, oxygen therapy, mechanical and intubation support, CPAP, a broad-spectrum antibiotic, treatment of underlying causes, chest physiotherapy, and nebulization. 

What is the Prognosis of Atelectasis?

The prognosis of atelectasis is fair.