What is Atherosclerotic Ischemic Renal Disease?

Atherosclerotic Ischemic Renal Disease
Scleroderma renal crisis and activation of the complement system. (A) Masson trichrome blue of a renal arteriole with intimal edema and onion-skin lesion narrowing the lumen (obj. ×25). (B) Masson trichrome blue of a glomerulus showing arteriolar thrombosis at the vascular pole. On light microscopy, most glomeruli appeared ischemic or even necrotic; in the remaining intact glomeruli, focal signs of mesangiolysis were present (obj. ×20). (C, D) C4d deposits identified by immunofluorescence in the wall of a renal arteriole (C) and glomerular capillaries (D). (E, F) Immunohistochemistry showing C5b-9 deposits in the endothelium of a renal arteriole (E) and a nonnecrotic glomerulus (F). (G) Ex vivo C5b-9 deposition induced by the serum of the patient. Relative surface area covered by C5b-9 staining after incubation of unstimulated (resting) or ADP-activated HMEC-1 for 4 hours with serum from the patient at admission (red bars), after 7 daily sessions of PEX (orange bars), and after 2 doses of eculizumab (green bars). C5b-9 deposits were normalized under eculizumab. Normal values <150% (dotted line). ADP = adenosine diphosphate, HMEC-1 = human microvascular endothelial cells-1, PEX = plasma exchange. Complement activation and effect of eculizumab in scleroderma renal crisis: Medicine. Not altered. CC.

Atherosclerotic ischemic renal disease is a renal inadequacy associated with main renal artery stenosis and/or occlusion.

What is the Pathology of Atherosclerotic Ischemic Renal Disease?

The pathology of atherosclerotic ischemic renal disease is:

-Etiology: The cause of atherosclerotic ischemic renal disease is renal arterial stenosis.

-Genes involved: Unknown. 

-Pathogenesis: The sequence of events that lead to atherosclerotic ischemic renal disease follows bilateral renal arterial stenosis.

-Morphology: The morphology associated with atherosclerotic ischemic renal disease shows necrotized renal tissue.

-Histology: Thickened, muscular arteries that may be calcified. 

How does Atherosclerotic Ischemic Renal Disease Present? 

Patients with atherosclerotic ischemic renal disease typically more common in males present at the age range of old age. The symptoms, features, and clinical findings associated with atherosclerotic ischemic renal disease include hematuria, proteinuria, accelerated hypertension, and renal failure, and end stage renal failure symptoms.

How is Atherosclerotic Ischemic Renal Disease Diagnosed? 

Atherosclerotic ischemic renal disease is diagnosed through arteriographic studies.

How is Atherosclerotic Ischemic Renal Disease Treated? 

Atherosclerotic ischemic renal disease is treated by medical care such as beta blockers, ARBs, ACE inhibitors. Dialysis, surgical care such as revascularization, and transplant.

What is the Prognosis of Atherosclerotic Ischemic Renal Disease?

The prognosis of atherosclerotic ischemic renal disease is poor, associated with ESRD. 

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Last updated on May 24, 2022