What is Basaloid Anal Transition Zone Tumor?

Basaloid Anal Transition Zone Tumor
Histological analysis of the anal transition zone at various time points in FVB/N mice during DMBA treatment time course.Anal histology identified by a trained pathologist for each time point (25 mice/group) following treatment with and without DMBA (0.12μmole topically to anus weekly). A) H&E staining of animals not treated with DMBA at the 5 week timepoint reveals normal epithelium. (B) Following 5 weeks of DMBA treatment, there is inflammation seen on H&E staining. (C) At 10 weeks of DMBA treatment there is histological evidence of low-grade dysplasia. (D) Low-grade dysplasia is present at 15 weeks of DMBA treatment and (E) high-grade dysplasia at 20 weeks of DMBA treatment. All images are acquired at 20x magnification. Dysregulation of Autophagy Contributes to Anal Carcinogenesis. PLoS ONE. Not Altered. CC.

Basaloid anal transition zone tumor is the pattern mixed with squamous-basaloid. Basaloid tumors must be differentiated from a basal cell carcinoma extending from perianal skin.

What is the Pathology of Basaloid Anal Transition Zone Tumor?

The pathology of basaloid anal transition zone tumor is:

-Etiology: The cause of basaloid anal transition zone tumor is STD, increased spinchter tone, other diseases.

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to basaloid anal transition zone tumor arises from the entodermal-ectodermal junctional zone of the anal canal at or above the dentate line particular the presence of palisading of the nuclei at the periphery of the clumps of tumour cells, but are potentially metastasizing tumours.

-Histology: The histology associated with basaloid anal transition zone tumor shows palisading solid circumscribed clumps of tumour cells containing small, round, or ovoid nuclei which are regular in shape and size.

How does Basaloid Anal Transition Zone Tumor Present?

Patients with basaloid anal transition zone tumor typically more in females at age of 41 to 80 years. The symptoms, features, and clinical findings associated with basaloid anal transition zone tumor include the feeling of a lump or mass at the anal opening, persistent or recurring pain in the anal area, persistent or recurrent itching.

How is Basaloid Anal Transition Zone Tumor Diagnosed?

Basaloid anal transition zone tumor is diagnosed by anoscopy, flexible sigmoidoscopy, and biopsy.

How is Basaloid Anal Transition Zone Tumor Treated?

Basaloid anal transition zone tumor is treated by radiotherapy.

What is the Prognosis of Basaloid Anal Transition Zone Tumor?

The prognosis of basaloid anal transition zone tumor is poor. 

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Last updated on May 25, 2022