(A) Control rats receiving saline vehicle showed the normal histological structure of the hepatic lobule. (B) Rats that received silymarin (100 mg/kg p.o.) showed normal hepatic histology with few Kupffer cell activation (arrow). (C) Rats that received tangeretin (100 mg/kg p.o.) showed slight hydropic degeneration of hepatocytes (arrow). (D) The cisplatin-treated group showed dilatation and congestion of the central vein and hepatic sinusoids (arrow). (E) Liver of rat from cisplatin-treated group demonstrated congestion of central vein (short arrow), cytoplasmic vacuolization of hepatocytes (long arrow), and focal hepatic necrosis associated with inflammatory cell infiltration (arrowhead) (F, G) Silymarin and tangeretin pre-treatment revealed attenuated morphological modifications with resolving Kupffer cell activation (arrow). Tangeretin Alleviates Cisplatin-Induced Acute Hepatic Injury in Rats: Targeting MAPKs and Apoptosis: Omar HA, Mohamed WR, Arab HH, Arafa el-SA - PloS one (2016). Not altered. CC.