(A) Schematic view of thymic central tolerance. After positive selection (not depicted), simple positive (SP) thymocytes undergo a process of negative selection. or (TCR) with high affinity for self (dark colors) are clonally deleted. (B) Peripheral T cell tolerance in the lymph nodes (LNs). References related to lymph node stromal cell contributions are indicated (numbers). Shaping of Peripheral T Cell Responses by Lymphatic Endothelial Cells: Frontiers in Immunology. Not altered. CC.