Chronic inflammatory demyelinating polyneuropathy is an immune-mediated inflammation of the neurons manifesting as a symmetric demyelinating disease.

What is the Pathology of Chronic Inflammatory Demyelinating Polyneuropathy?

The pathology of chronic inflammatory demyelinating polyneuropathy is: 

-Etiology: The cause of chronic inflammatory demyelinating polyneuropathy is immune-mediated.

-Genes involved: NA.

-Pathogenesis: The sequence of events that lead to chronic inflammatory demyelinating polyneuropathy results from cell-mediated immune response, convoyed by segmented demyelination brought by activated macrophages produced during the infection.

-Morphology: NA.

-Histology: The histology associated with chronic inflammatory demyelinating polyneuropathy shows endoneurial/perivenular lymphocytes and macrophages infiltration.

How does Chronic Inflammatory Demyelinating Polyneuropathy Present? 

Patients with chronic inflammatory demyelinating polyneuropathy typically affect both sexes present at an age range of any age. The symptoms, features, and clinical findings associated with chronic inflammatory demyelinating polyneuropathy include limb weakness, hands and feet tingling and numbness, orthostatic dizziness, abnormal gait, and deep tendon reflexes absent.

How is Chronic Inflammatory Demyelinating Polyneuropathy Diagnosed? 

Chronic inflammatory demyelinating polyneuropathy is diagnosed through clinical presentations, laboratory studies which include CBCs, ESR, biochemical profile, urine immune-electrophoresis, and antinuclear antibody (ANA) level. Imaging studies- spine MRI, electromyography (EMG) and peripheral nerve biopsy.

How is Chronic Inflammatory Demyelinating Polyneuropathy Treated? 

Chronic inflammatory demyelinating polyneuropathy is treated through plasmapheresis and administration of immunosuppressive agents.

What is the Prognosis of Chronic Inflammatory Demyelinating Polyneuropathy?

The prognosis of chronic inflammatory demyelinating polyneuropathy is fair, complete recovery but more frequently recurring bouts of symptomatic disease.