What is Clear Cell Carcinoma of the Ovary?

Clear Cell Carcinoma of the Ovary
(a) Photomicrograph shows sheets of clear cells with cytoplasmic clearing [arrow] (H and E, ×100). Other areas show papillary pattern, where nuclear hobnailing. (b) Squamous morules are also seen (H and E, ×100); (c) there are flattened squamous cells [black arrow] as well as squamous cells with nuclear ghosts and intracellular bridging. Inset shows multinucleated giant cells with engulfed keratinous material (H and E, ×200; Inset: H and E, ×200). (d) Another area shows clear cells on the left and a squamous morule on the right with preserved nuclei [arrow] (H and E, ×200). Clear cell carcinoma of ovary with squamous metaplasia: A unique histopathological observation. Das P, Singh G, Kumar N, Hariprasad R, Dinda AK, Kumar L, Mathur SR - Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology (2011). Not Altered. CC.

Clear cell carcinoma of the ovary is a distinct entity of epithelial ovarian cancer which is Malignant epithelial tumor composed of clear, eosinophilic or hobnail cells with tubulocystic, papillary and solid growth patterns.

What is the Pathology of Clear Cell Carcinoma of the Ovary?

The pathology of clear cell carcinoma of the ovary is:

-Etiology: The cause of clear cell carcinoma of the ovary is endometriosis or clear cell adenofibroma, mutations in genes.

-Genes involved:  ESPL1 and CDC25C genes.

-Pathogenesis: The sequence of events that lead to clear cell carcinoma of the ovary are malignant proliferation.

-Morphology: The morphology associated with clear cell carcinoma of the ovary shows cysts with chocolate colored fluid, spongy appearance of cysts.

-Histology: The histology associated with clear cell carcinoma of the ovary shows Nuclear pseudoinclusions, uniform nuclear atypia, Peritumoural infiltrate.

How does Clear Cell Carcinoma of the Ovary Present?

Patients with clear cell carcinoma of the ovary typically females with mean age of 55 -56 years age. The symptoms, features, and clinical findings associated with clear cell carcinoma of the ovary include: pelvic mass, lump in the abdomen or pain or discomfort. 

How is Clear Cell Carcinoma of the Ovary Diagnosed?

Clear cell carcinoma of the ovary is diagnosed by: microscopic examination, blood test for CA-125, ultrasound, CT scan, MRI.   

How is Clear Cell Carcinoma of the Ovary Treated?

Clear cell carcinoma of the ovary is treated by: total abdominal hysterectomy and bilateral salpingo-oophorectomy and omentectomy, Adjuvant chemoradiation, cytoreductive surgery.

What is the Prognosis of Clear Cell Carcinoma of the Ovary?

The prognosis of clear cell carcinoma of the ovary is excellent for first or second stage cancers. But for 3rd or 4th stage the overall survival is 52%.   

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Last updated on May 26, 2022