What is Crescentic Glomerulonephritis?

Crescentic Glomerulonephritis
Light micrograph of crescentic glomerulonephritis with fibrinoid necrosis, showing mild mesangial expansion and minimal increase in cellularity without endocapillary proliferation. Subepithelial spikes were noted on the silver stain. Pauci-Immune Necrotizing and Crescentic Glomerulonephritis with Membranous Lupus Nephritis, Fifteen Years after Initial Diagnosis of Secondary Membranous Nephropathy: Burkhart R, Shah N, Abel M, Oliver JD, Lewin M - Case reports in nephrology (2015). Not altered. CC.

Crescentic Glomerulonephritis is a chronic disease of the glomerular that is immune mediated. 

What is the Pathology of Crescentic Glomerulonephritis?

The pathology of crescentic glomerulonephritis is the study of the disease of the glomerular leading to inflammation and injury. 

-Etiology: The cause of crescentic glomerulonephritis is autoimmune antibodies.

-Genes involved: Unknown. 

-Pathogenesis: The sequence of events that lead to crescentic glomerulonephritis macrophages involve producing toxins that lead to destruction of the glomerular leading to end stage renal failure.

-Morphology: Not applicable. 

-Histology: The histology associated with crescentic glomerulonephritis shows glomerular crescent formation, fibrin deposition.

How does Crescentic Glomerulonephritis Present? 

Patients with crescentic glomerulonephritis typically are both male and female present at the age range of 60-85 years. The symptoms, features, and clinical findings associated with crescentic glomerulonephritis include hematuria, proteinuria, imparued GFR.

How is Crescentic Glomerulonephritis Diagnosed? 

Crescentic glomerulonephritis is diagnosed history, urinalysis, kidney biopsy.

How is Crescentic Glomerulonephritis Treated? 

Crescentic glomerulonephritis is treated with immunosuppressors, corticosteroids, and plasma exchange.

What is the Prognosis of Crescentic Glomerulonephritis?

The prognosis of crescentic glomerulonephritis is fair with partial or total recovery.