Infiltration of chronic inflammatory cells in gouty tophus tissues. (a) Tophus tissue sections from patients with chronic gouty arthritis were processed for hematoxylin-eosin (HE) staining. * indicates monosodium urate monohydrate (MSU) crystals, and ** represents osteolytic lesions. (b) Serial sections were processed for immunohistochemical staining using anti-CD3, anti-CD4, anti-CD8, anti-CD20, anti-CD68, and anti-c-kit antibodies (brown). Scale bar in a = 500 μm; scale bars in b = 50 μm. Bone destruction by receptor activator of nuclear factor κB ligand-expressing T cells in chronic gouty arthritis: Lee SJ, Nam KI, Jin HM, Cho YN, Lee SE, Kim TJ, Lee SS, Kee SJ, Lee KB, Kim N, Park YW - Arthritis research & therapy (2011). Not altered. CC.