What is Diabetes Mellitus Type 2?

Diabetes Mellitus Type 2
Phosphorylation of FakSer732 is decreased in β-cells in humans with type 2 diabetes. A: The presence of FakSer732 phosphorylation in β-cell was assessed by immunofluorescence (P-FakSer732, red; Insulin, green; Nuclei, blue) in surgical pancreatic tissue obtained from nondiabetic control subjects (n = 4) and subjects with type 2 diabetes (n = 6). B: The graph represents the quantification of β-cells positive for P-FakSer732, expressed in %. *P < 0.05, significant differences. (A high-quality digital representation of this figure is available in the online issue.)Cyclin-dependent kinase 5 promotes pancreatic β-cell survival via Fak-Akt signaling pathways. Daval M, Gurlo T, Costes S, Huang CJ, Butler PC - Diabetes (2011). Not Altered. CC.

Diabetes mellitus type 2 is a metabolic disorder caused by both lack of the beta cells to allow the action of insulin to the cells and reduced secretion of insulin.

What is the Pathology of Diabetes Mellitus Type 2?

The pathology of diabetes mellitus type 2 is: a metabolic disorder characterized by the beta cells causing resistance to the action of insulin and destruction of beta cells. 

-Etiology: The cause of diabetes mellitus type 2 is lifestyle factors, and obesity.

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to diabetes mellitus type 2 based on the environmental and genetic factors causes the cells to be resistant to insulin leading to diabetes. In contrast, the dysfunction of the beta cells causes reduced insulin production.

-Morphology: The morphology associated with diabetes mellitus type 2 show the macrovascular disease of the arteries, microangiopathy of the small vessels, nephropathy, retinopathy, and neuropathy.

-Histology: None.

How does Diabetes Melitus Type 2 Present? 

Patients with diabetes melitus type 2 are typical of both genders and present at an age range of  40 years and above but can be seen in children and adolescents. The symptoms, features, and clinical findings associated with diabetes mellitus type 2 include polyuria, polydipsia, retinopathy, blurred vision, and atherosclerosis.

How is Diabetes Melitus Type 2 Diagnosed? 

Diabetes melitus type 2 is diagnosed by history taking and laboratory studies for any elevated levels of glucose and plasma glucose levels.

How is Diabets Meliutus Type 2 Treated? 

Diabetes mellitus type 2 is treated by managing the symptoms controlling blood sugar levels, blood pressure, smoking cessation, and regular exercise to help in weight loss.

What is the Prognosis of Diabetes Melitus Type 2?

The prognosis of diabetes mellitus type 2 is fair when there is proper management of glucose levels.