Diphtheria infectious neuropathy is an acute demyelinating polyneuropathy, peripheral nerve involvement resulting from the effects of the diphtheria exotoxin.

What is the Pathology of Diphtheria Infectious Neuropathy?

The pathology of diphtheria infectious neuropathy is:

-Etiology: The cause of diphtheria infectious neuropathy is diphtheria exotoxin

-Genes involved: NA.

-Pathogenesis: The sequence of events that lead to diphtheria infectious neuropathy results from diphtheria exotoxin effects on the peripheral nerves- selective demyelination of axons.

-Morphology: NA.

-Histology: NA.

How does Diphtheria Infectious Neuropathy Present? 

Patients with diphtheria infectious neuropathy typically have no gender predilection present at age range of any age. The symptoms, features, and clinical findings associated with diphtheria infectious neuropathy include orthostatic hypotension, facial pallor, anhidrosis, hypohidrosis pruritus, dysesthesia, allodynia, and hyperalgesia. Peripheral nerve affected by diphtheria exotoxin characterized by loss of vibratory sensation and proprioception.

How is Diphtheria Infectious Neuropathy Diagnosed? 

Diphtheria infectious neuropathy is diagnosed through the clinical presentation, laboratory studies such as immunoelectrophoresis, basic metabolic panel, LFTs. Imaging studies may also be useful.

How is Diphtheria Infectious Neuropathy Treated? 

Diphtheria infectious neuropathy is treated through pharmacologic therapy, immunomodulatory therapy.

What is the Prognosis of Diphtheria Infectious Neuropathy?

The prognosis of diphtheria infectious neuropathy is fair, with proper management.