Disseminated Intravascular Coagulation. Pathophysiological considerations in the clinical presentation of DIC. Systemic activation of coagulation together with cellular activation (endothelial cells, neutrophils, and platelets) leads to excessive thrombin generation and its functional consequences.Abbreviations: FDP, fibrin degradation products; NETs, neutrophil extracellular traps; PAR, protease-activated receptor. Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation. Annals of Laboratory Medicine. Not altered. CC.