What is Fibrillary Glomerulonephritis?

Fibrillary Glomerulonephritis
Electron microscopic features of subendothelial deposits and fibrillary glomerulonephritis. (a) Electron micrograph image revealing granular subendothelial deposits and small intracapillary deposits. (b) Electron micrograph image showing infiltration of fibrillar materials in the mesangium. (c) Irregular accumulations of randomly arranged nonbranching fibrils in the mesangium. Simultaneous occurrence of fibrillary glomerulonephritis and renal lesions in nonmalignant monoclonal IgM gammopathy: Wu CK, Leu JG, Yang AH, Tarng DC, Tung HY, Chiang SS - BMC nephrology (2016). Not altered. CC.

Fibrillary glomerulonephritis is a disease of the glomerulus that is characterized by the deposition of the fibril proteins in the glomerulus. 

What is the Pathology of Fibrillary Glomerulonephritis?

The pathology of fibrillary glomerulonephritis is:

-Etiology: The cause of fibrillary glomerulonephritis is malignancies, autoimmune diseases, 

-Genes involved: Unknown. 

-Pathogenesis: The sequence of events that lead to fibrillary glomerulonephritis

-Morphology: The morphology associated with fibrillary glomerulonephritis shows an accumulation of nonbranching randomly arranged fibrils.

-Histology: The histology associated with fibrillary glomerulonephritis shows mesangial expansion, endocapillary proliferation.

How does Fibrillary Glomerulonephritis Present? 

Patients with fibrillary glomerulonephritis typically male present at the age range of 55-60 years. The symptoms, features, and clinical findings associated with fibrillary glomerulonephritis include hematuria, proteinuria, renal insufficiency, and hypertension.

How is Fibrillary Glomerulonephritis Diagnosed? 

Fibrillary glomerulonephritis is diagnosed by microscopic examination.

How is Fibrillary Glomerulonephritis Treated? 

Fibrillary glomerulonephritis is treated with rituximab.

What is the Prognosis of Fibrillary Glomerulonephritis?

The prognosis of fibrillary glomerulonephritis is poor.