Hemolytic anemia due to red blood cell trauma is disorder of the red cells caused by circumstances involving trauma, cardiac valve prostheses, or narrowing or obstruction.
What is the Pathology of Anemia Due to Red Blood Cell Trauma?
The pathology of anemia due to red blood cell trauma is:
-Etiology: The cause of anemia due to red blood cell trauma is narrowing of vessels due to fibrin deposition, other conditions such as malignant hypertension, thrombotic thrombocytopenic purpura (TTP), hemolytic-uremic syndrome (HUS), disseminated cancer.
-Genes involved: None.
-Pathogenesis: The sequence of events that lead to anemia due to red blood cell trauma; When red cells are squeeze through abnormally narrowing of vessels due to fibrin deposition causing microangiopathic hemolytic anemia. Hemolysis as a results of shear stresses due to turbulent blood flow and irregular pressure gradients.
-Morphology: The morphology associated with anemia due to red blood cell trauma shows vessels narrowing, fibrin deposit on blood vessels.
-Histology: The histology associated with anemia due to red blood cell trauma shows burr cells, helmet cells, and triangle cells.
How does Anemia Due to Red Blood Cell Trauma Present?
Patients with anemia due to red blood cell trauma typically common in females than males present at an age range of childhood and adulthood. The symptoms, features, and clinical findings associated with anemia due to red blood cell trauma include tachycardia, abdominal pain, dyspnea, dark urine angina, weakness.
How is Anemia Due to Red Blood Cell Trauma Diagnosed?
Anemia due to red blood cell trauma is diagnosed through medical presentation, laboratory studies-CBC count, peripheral blood smear, indirect bilirubin, LDH levels, and serum haptoglobin.
How is Anemia Due to Red Blood Cell Trauma Treated?
Anemia due to red blood cell trauma is treated through managing underlying conditions, medical care-iron therapy, erythropoietin therapy, and transfusion.
What is the Prognosis of Anemia Due to Red Blood Cell Trauma?
The prognosis of anemia due to red blood cell trauma is fair depending on the management of the underlying cause.
