What is Henoch-Schönlein Purpura?

Henoch-Schönlein Purpura
Kidney involvement of Henoch–Schönlein purpura. The biopsy reveals 9% segmental loop necrosis. A) Polymorphonuclear cell infiltration and B) segmental mesangial proliferation. C) Periodic acid–Schiff stain with hematoxylin and eosin stain, ×400. D) The mesangial deposit is observed on electron microscopy. E) The immunoglobulin A deposit is 3+ on immunofluorescence microscopy. Overall, grade II Henoch-Schönlein purpura nephritis is diagnosed based on the International Study of Kidney Disease in Children grading system [7]. High-dose methylprednisolone pulse therapy for treatment of refractory intestinal involvement caused by Henoch-Schönlein purpura: a case report. Kang HS, Chung HS, Kang KS, Han KH - Journal of medical case reports (2015). Not Altered. CC.

Henoch-Schönlein purpura is a disorder that causes the small blood vessels in the skin, joints, intestines, and kidneys to become inflamed and bleed.

What is the Pathology of Henoch-Schönlein Purpura?

The pathology of Henoch-Schönlein purpura is:

-Etiology: The cause of Henoch-Schönlein purpura is typically an infection.

-Pathogenesis: The sequence of events that lead to Henoch-Schönlein purpura is the body’s small blood vessels that become inflamed, which can cause bleeding in the skin, abdomen, and kidneys. 

-Histology: The histology associated with Henoch-Schönlein purpura shows IgA-antibody immune complexes deposition in the small vessels.

How does Henoch-Schönlein Purpura Present?

Patients with Henoch-Schönlein purpura typically are males present in the age range of all age groups. The symptoms, features, and clinical findings associated with Henoch-Schönlein purpura include a purplish rash that is typically on the lower legs or buttocks.

How is Henoch-Schönlein Purpura Diagnosed?

Henoch-Schönlein purpura is diagnosed with lab tests, such as blood and urine tests. A biopsy may also be performed.

How is Henoch-Schönlein Purpura Treated?

Henoch-Schönlein purpura is treated with corticosteroids, such as prednisone.

What is the Prognosis of Henoch-Schönlein Purpura?

The prognosis of Henoch-Schönlein purpura is good.