What is Histoplasma Fungal Infection?

Histoplasma Fungal Infection
(A) Peripheral blood shows neutrophils with toxic granules and two intra-cytoplasmic yeast forms of Histoplasma capsulatum in the cell on the left (May-Grunwald Giemsa, ×1,000). Inset: The fungus was brightly positive for periodic acid–Schiff stain (hematoxylin counterstain, ×1,000). (B) Hemodilute bone marrow smears showed dysgranulopoiesis with 5% blasts (May-Grunwald Giemsa, ×1,000). Inset: Ring sideroblasts comprised 32% of all cells (Perls' Prussian Blue reaction with a neutral red counterstain, ×1,000). (C) Bone marrow biopsy showed intracellular yeast forms (hematoxylin and eosin, ×400). Inset: These were positive for Grocott's silver methenamine stain (methyl green counterstain, ×1,000). (D) Lactophenol cotton blue wet-mount preparation of the isolated mold shows thick-walled and tuberculate macroconidia, with a close-up in the inset (lactophenol cotton blue stain, ×1,000). A case of histoplasmosis in a patient with MDS/MPN-U: Blood research. Not altered. CC.

Histoplasma fungal infection is an infection caused by breathing in spores of a fungus often found in bird and bat droppings.

What is the Pathology of Histoplasma Fungal Infection?

The pathology of histoplasma fungal infection is:

-Etiology: The cause of histoplasma fungal infection is breathing in spores of a fungus often found in bird and bat droppings.

-Genes involved: Not applicable. 

-Pathogenesis: The sequence of events that lead to histoplasma fungal infection are:

-Morphology: The morphology associated with histoplasma fungal infection shows delicate, septate hyphae, 1 – 2 microns thick, with large rough walled macroconidia 5 – 15 microns.

-Histology: The histology associated with histoplasma fungal infection shows isolated intracellular organisms and large aggregates surrounded by chronic inflammatory cells and fibroblasts.

How does Histoplasma Fungal Infection Present?

Patients with histoplasma fungal infection typically are all genders of all ages. The symptoms, features, and clinical findings associated with histoplasma fungal infection include chest pain, body aches, fever, chils, and headaches.

How is Histoplasma Fungal Infection Diagnosed?

Histoplasma fungal infection is diagnosed by blood test or a urine test.

How is Histoplasma Fungal Infection Treated?

Histoplasma fungal infection is treated by antibiotics such as Itraconazole.

What is the Prognosis of Histoplasma Fungal Infection?

The prognosis of histoplasma fungal infection is fair to poor. If untreated, subacute progressive disseminated histoplasmosis results in death within 2-24 months.

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Last updated on May 24, 2022