What is HIV/AIDS Infectious Neuropathy?

HIV/AIDS Infectious Neuropathy
HIV/AIDS Infectious Neuropathy. Two representative skin biopsy samples of HIV-infected participants. (A) Participant from HIV-SN peripheral neuropathy group demonstrating the complete absence of small unmyelinated sensory nerve fibers reaching epidermis. Subepidermal dermal plexus fibers are present (blue arrow) as identified by pan-neuronal marker PGP 9.5. (B) Participant from HIV–No SN group with normal counts of small unmyelinated nerve fibers (black arrows) reaching epidermis beyond dermal-epidermal junction (red dotted line), and positive dermal plexus staining (blue arrows). Original magnification, 40×. Scale bar = 50 μm. HIV-SN, HIV sensory neuropathy; HIV–No SN, no HIV sensory neuropathy. Sensory, psychological, and metabolic dysfunction in HIV-associated peripheral neuropathy: A cross-sectional deep profiling study: Phillips TJ, Brown M, Ramirez JD, Perkins J, Woldeamanuel YW, Williams AC, Orengo C, Bennett DL, Bodi I, Cox S, Maier C, Krumova EK, Rice AS - Pain (2014). Not altered.

HIV/AIDS Infectious neuropathy is the most recurrent neurological complication of HIV infection.

What is the Pathology of HIV/AIDS Infectious Neuropathy?

The pathology of HIV/AIDS infectious neuropathy is: 

-Etiology: The cause of HIV/AIDS infectious neuropathy is HIV complication.

-Genes involved: NA.

-Pathogenesis: The sequence of events that lead to HIV/AIDS infectious neuropathy results from the effect of HIV on the various motor and sensory nerves of distal parts of the limbs, causing HIV polyneuropathy.

-Morphology: NA.

-Histology: NA.

How does HIV/AIDS Infectious Neuropathy Present? 

Patients with HIV/AIDS infectious neuropathy typically have no gender preference present at the age range of any age. The symptoms, features, and clinical findings associated with HIV/AIDS infectious neuropathy include paresthesias, pain at the hands and feet, numbness, and feet and hands muscles weakness.

How is HIV/AIDS Infectious Neuropathy Diagnosed? 

HIV/AIDS infectious neuropathy is diagnosed through clinical presentations, electromyography, nerve conduction studies, skin biopsies to evaluate cutaneous nerve innervation.

How is HIV/AIDS Infectious Neuropathy Treated? 

HIV/AIDS infectious neuropathy is treated by good control of the HIV infection, anti-seizure medications, analgesics, antidepressants therapy for neurologic pain. Treat accordingly for GBS due to HIV.

What is the Prognosis of HIV/AIDS Infectious Neuropathy?

The prognosis of HIV/AIDS infectious neuropathy is fair. The condition recurs frequently.

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Last updated on May 23, 2022