Glycine (G)–Tryptophan (W) bodies (GWBs) and microRNA regulation in the innate immune response. (A) Using a human prototype serum, we identified a novel cytoplasmic domain (green) in HEp-2 anti-nuclear antibody assay; nuclei are counterstained blue with DAPI. (B) Our proposed model of microbial tolerance and cross-tolerance is regulated by miRNAs via targeting of the Myddosome complex. Our Journey from the Study of Human Autoantibodies to the microRNA World: Fredenburg KM, Chan EK - Frontiers in immunology (2015). Not altered. CC.