Indeterminate colitis is originally referred to those 10-15% of cases of inflammatory bowel disease IBD in which there was difficulty distinguishing between ulcerative colitis UC and Crohn’s disease CD in the colectomy specimen.

What is the Pathology of Indeterminate Colitis?

The pathology of indeterminate colitis is:

-Etiology: The cause of indeterminate colitis is unknown however it might be an autoimmune disease.

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to indeterminate colitis are inflammation.

-Histology: The histology associated with indeterminate colitis shows diffuse and uniform chronic active colitis.

How does Indeterminate Colitis Present?

Patients with indeterminate colitis typically women at any age. The symptoms, features, and clinical findings associated with indeterminate colitis include abdominal pain and cramping, diarrhea, weight loss, reduced appetite, fever, and fatigue.

How is Indeterminate Colitis Diagnosed?

Indeterminate colitis is diagnosed by anti-saccharomyces cerevisiae antibody ASCA and perinuclear antineutrophil cytoplasmic antibody pANCA.

How is Indeterminate Colitis Treated?

Indeterminate colitis has no cure. Sometimes surgery to remove some symptoms of inflammatory bowel disease.  

What is the Prognosis of Indeterminate Colitis?

The prognosis of indeterminate colitis is good.