(A) Urinary bladder section from control animal showing a normal mucosa (arrow 1) and muscular coat with fluid in the lumen (arrow 2) (H&E stain X100). (B) Urinary bladder section from CYCL-treated animal showing edema, congestion (arrow 1), petechial hemorrhage (arrow 2) and inflammation in the lamina propria (arrow 3) with protein aqueous material into the lumen as well as a desquamative epithelium (arrow 4) (H&E stain X200). (C) Urinary bladder section from CYCL-treated animal showing edema, congestion, polymorphonuclear leukocytes and occasional erythroctes (arrow 1), lymphocytes (arrow 2) and plasma cell (arrow 3) infiltration with acute and chronic inflammation (PSA stain X400). (D) Urinary bladder section from GA followed by CYCL-treated animal showing mild residual nonspecific inflammation with almost normal structure (H&E stain X200). GA was given in a dose of 7.5 g/kg/day for 6 days in drinking water before and during the experimental period (24 h) of CYCL that was given in a dose of 150 mg/kg i.p. CYCL induced marked histological changes in rat urinary bladder that were almost completely prevented by GA.Acacia Senegal gum exudate offers protection against cyclophosphamide-induced urinary bladder cytotoxicity. Al-Yahya AA, Al-Majed AA, Gado AM, Daba MH, Al-Shabanah OA, Abd-Allah AR - Oxidative medicine and cellular longevity (2009 Sep-Oct). Not Altered. CC.