What is Lambert-Eaton Myasthenic Syndrome?

Lambert-Eaton Myasthenic Syndrome
Lambert-Eaton Myasthenic Syndrome. Pathological and cytological findings in an SCLC patient with LEMS. Specimens were obtained by cervical lymph node biopsy on February 14, 2002. Paraffin-embedded sections were stained with antibody using the polymer method (The Dako Envision™ FLEX, Dako Japan, Tokyo, Japan) and signal was developed with diaminobenzidine (DAB). Sections were counterstained with hematoxylin. Positive staining for markers in cytoplasm and on cell membrane was indicated in brown. a There are dense sheets of small cells with nuclear molding and necrosis (hematoxylin–eosin staining). b CD56 was diffusely and strongly positive on cell membrane. c Chromogranin A was diffusely and moderately expressed in cytoplasm. d Synaptophysin was focally and weakly expressed in cytoplasm. Relapse of both small cell lung cancer and Lambert-Eaton myasthenic syndrome after a 13-year disease-free survival period: Asano F, Watanabe K, Shinkai M, Tei Y, Mishina K, Tanabe M, Ishii H, Shinoda M, Shimokawaji T, Kudo M, Kaneko T - Chinese journal of cancer (2016). Not altered. CC.

Lambert-Eaton myasthenic syndrome is an autoimmune disease of the neuromuscular junction caused by antibodies that block the presynaptic release of acetylcholine.

What is the Pathology of Lambert-Eaton Myasthenic Syndrome?

The pathology of Lambert-Eaton myasthenic syndrome is:

-Etiology: The cause of lambert-eaton myasthenic syndrome is the presence of small cell lung cancer, autoimmune diseases, 

-Genes involved: NA.

-Pathogenesis: The sequence of events that lead to lambert-eaton myasthenic syndrome antibodies attack the voltage-gated calcium channels causing insufficient depolarization which leads to a low release of acetylcholine.

-Morphology: NA.

-Histology: NA.

How does Lambert-Eaton Myasthenic Syndrome Present? 

Patients with Lambert-Eaton myasthenic syndrome typically are both male and present at the age range of 30- 60 years. The symptoms, features, and clinical findings associated with lambert-eaton myasthenic syndrome include proximal muscle weakness, depressed tendon reflexes, post-tetanic potentiation, and autonomic changes.

How is Lambert-Eaton Myasthenic Syndrome Diagnosed? 

Lambert-Eaton myasthenic syndrome is diagnosed by electromyography, physical examination, complete blood count, repetitive nerve stimulation.

How is Lambert-Eaton Myasthenic Syndrome Treated? 

Lambert-Eaton myasthenic syndrome is treated by treating the underlying malignancy, avoiding drugs that increase muscle weakness. 

What is the Prognosis of Lambert-Eaton Myasthenic Syndrome?

The prognosis of the lambert-eaton myasthenic syndrome is hard to determine since the type of cancer one presents with is the main key.

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Last updated on May 23, 2022