Expression of pro-apoptotic markers (Bax, Fas, p53, Caspase-3) in epidermal keratinocytes of advanced HCV liver disease patients (a,c,e,g) and in controls (b,d,f,h) respectively showing the following: Significant increase of cytoplasmic expression of Bax staining in basal and squamous cell layers in patients (a) when compared to that confined to the basal cell layer of controls (b) (Immunohistochemical, ×400).Significant increase of membranous expression of Fas staining in basal and lower 2/3 of squamous cell layers in patients (c) when compared to that confined to the basal cell layer of controls (d) (Immunohistochemical, ×400). Significant increase of nuclear expression of P53 staining in basal and lower 2/3 of squamous cell layers in patients (e) when compared to that confined to the basal cell layer of controls (f) (Immunohistochemical, ×200). Significant increase of cytoplasmic expression of Caspase 3 staining in basal and squamous cell layers in patients (g) when compared to minimal staining confined to the basal cell layer of controls (h) (Immunohistochemical, ×400). Expression of apoptosis regulatory markers in the skin of advanced hepatitis-C virus liver patients: El-Domyati M, Abo-Elenin M, El-Din WH, Abdel-Wahab H, Abdel-Raouf H, El-Amawy T, Barakat M, Hamdy M - Indian journal of dermatology (2012). Not altered. CC.