What is Liver Failure Related Disorder of Hemostasis?

Liver Failure Related Disorder of Hemostasis
Pathological features of liver tissue under light microscope by HE (magnification 400x) and Masson staining (magnification 200x). Liver sections of normal, ALF, and ACLF group were stained with HE (a, b, and c) and Masson (d, e, and f), respectively. (a, d) Normal: the rats were from 0 h subgroup in ALF model; (b, e) “12 h” subgroup in ALF group; (c, f) “12 h” subgroup in ACLF group (HE: hematoxylin and eosin staining; ALF: acute hepatic failure; ACLF: acute-on-chronic liver failure). Deregulation of Regulatory T Cells in Acute-on-Chronic Liver Failure: A Rat Model. Mediators of Inflammation. Not Altered. CC.

Liver failure related disorder of hemostasis is the hemostatic disease due to liver dysfunction. 

The pathology of liver failure related disorder of hemostasis is:

-Etiology: The cause of liver failure-related disorder of hemostasis is cirrhosis.

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to liver failure-related disorder of hemostasis shows an imbalanced intestinal homeostasis results in a breach of the gut barrier and subsequent microbial translocation. Microbial translocation is an important pathogenic factor in the progression of chronic liver disease.

-Histology: The histology associated with liver failure related disorder of hemostasis shows panacinar hepatic necrosis with the collapse of the reticulin framework.

Patients with a liver failure-related disorder of hemostasis typically affects male and female present at the age range of 25-55 years. The symptoms, features, and clinical findings associated with liver failure related disorder of hemostasis include thrombocytopenia, reduced levels of coagulation factors and inhibitors, reduced levels of fibrinolytic proteins, and increased plasma levels of coagulation factor VIII and VWF, jaundice, malaise, ascites, nausea, and vomiting.

Liver failure-related disorder of hemostasis is diagnosed using blood tests and liver function tests. 

Liver failure-related disorder of hemostasis is treated by doing liver transplant, auxiliary partial orthotopic liver transplant, and usual antibiotics.

The prognosis of liver failure-related disorder of hemostasis is poor with an increased mortality rate.

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Last updated on May 24, 2022