What is Liver Injury?

Liver Injury
Main pathologic findings of drug-induced liver injury. (A) There are several centrilobular confluent necrosis at the acinar zone III with bridging necrosis connected to the adjacent vascular structure (H&E stain, × 40). (B) Trichrome stain showed an enlarged portal tract with minimal portal fibrosis (Trichrome stain, × 40). (C) The necrotic acinar zone III areas are mostly infiltrated by lipofusin pigment laden histiocytes. There is also surrounding chronic inflammatory cell infiltration (H&E stain, × 100). (D) Focal necrosis and acidophilic body formation of the hepatocytes with Kupffer cell hyperplasia are also present (H&E stain, × 200). Clinical Features of Drug-induced Liver Injury According to Etiology: Lee BM, Lee WC, Jang JY, Ahn P, Kim JN, Jeong SW, Park EJ, Lee SH, Kim SG, Cha SW, Kim YS, Cho YD, Kim HS, Kim BS - Journal of Korean medical science (2015). Not altered. CC.

Liver injury is a form of trauma sustained to the liver.

Liver injury may include:

  • Drug-induced liver injury
  • Toxin induced liver injury
  • Drug-induced liver injury is the liver injury caused by certain drugs
  • Toxin induced liver Injury is chemical-driven liver damage

What is the Pathology of Drug or Toxin Induced Liver Injury?

The pathology of drug and toxin-induced liver injury is:

-Etiology: The cause of drug and toxin-induced liver injury includes medications, herbal medications, dietary supplements, or other xenobiotics.

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to drug-induced liver injury usually involves the participation of a toxic drug or metabolite that either elicits an immune response or directly affects the biochemistry of the cell.

-Histology: The histology associated with drug-induced liver injury shows lobular disarray, rosette formation, and hemorrhage.

How does Drug-Induced Liver Injury Present?

Patients with drug-induced liver injury typically affect females present at the age range of 35-55. The symptoms, features, and clinical findings associated with the drug-induced liver injury include jaundice, belly pain, nausea, vomiting, lack of appetite, dark urine, and pale-colored stool.

How is Drug-Induced Liver Injury Diagnosed?

Drug-induced liver injury is diagnosed using liver biopsy. 

How is Drug-Induced Liver Injury Treated?

Drug-induced liver injury is treated by stopping the medication which is causing it.

What is the Prognosis of Drug-Induced Liver Injury?

The prognosis of drug-induced liver injury is good with usually reversible and benign.

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Last updated on May 24, 2022