What is Lobular Carcinoma in Situ?

Lobular Carcinoma in Situ
Representative photomicrographs: Case #95, lobular carcinoma in situ-ductal carcinoma in situ-invasive cancer triplet. (A), (B) Terminal duct lobular units involved by classic lobular carcinoma in situ (LCIS): (A) H & E, 40×; (B) H & E, 100×. (C), (D) High-grade ductal carcinoma in situ (DCIS) with solid and micropapillary patterns: (C) H & E, 40×; (D) H & E, 100×. (E), (F) Focus of high-grade DCIS (arrows) and associated invasive ductal carcinoma of no special type of moderate tubule formation and intermediate nuclear grade - histologic grade II/III: (E) H & E, 40×; (F) H & E, 100×.Clonal relatedness between lobular carcinoma in situ and synchronous malignant lesions. Andrade VP, Ostrovnaya I, Seshan VE, Morrogh M, Giri D, Olvera N, De Brot M, Morrow M, Begg CB, King TA - Breast cancer research : BCR (2012). Not Altered. CC.

Lobular Carcinoma in Situ is the lobulocentric proliferation of small uniform cells which fill and distend most of the acini in the involved lobule.

What is the Pathology of Lobular Carcinoma in Situ?

The pathology of lobular carcinoma in situ is:

-Etiology: The cause of lobular carcinoma in situ are the genetic mutations developed in a milk-producing gland of a breast.

-Genes involved: Mutations in the CDH1.

-Pathogenesis: The sequence of events that lead to lobular carcinoma in situ is when genetic mutations occur in the DNA of breast duct cells.

-Morphology: The morphology associated with lobular carcinoma in situ may include breast assymetry or a mass lesion.

-Histology: The histology associated with lobular carcinoma in situ shows terminal duct lobular unit with expanding acini and proliferation loosley cohesive of monomorphic cells.

How does Lobular Carcinoma in Situ Present?

Patients with lobular carcinoma in situ typically are older females.

How is Lobular Carcinoma in Situ Diagnosed?

Lobular carcinoma in situ is diagnosed by biopsy and histologic examination.

How is Lobular Carcinoma in Situ Treated?

Lobular carcinoma in situ is treated with lumpectomy or mastectomy, and possible sentinel lymph node biopsy.

What is the Prognosis of Lobular Carcinoma in Situ?

The prognosis of lobular carcinoma in situ is fair.

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Last updated on May 27, 2022