Pathological analysis of the male reproductive system in PIM1/PIM2 transgenic models.(A) H&E stating was used to evaluate the pathology of the seminal vesicle as well as the anterior, lateral, and ventral prostate lobes in WT and both transgenic models, which revealed normal and hyperproliferative grades, respectively. TgPIM1 and TgPIM2 seminal vesicles show areas of epithelial hyperplasia and adenomas. Arrows in TgPIM1/TgPIM2 seminal vesicles indicate immune infiltration, which was not found in WT tissues. The seminal vesicles scale bars indicates 100 μm (20X), and the anterior prostate scale bars indicate 200 μm (10X). (B) Following pathological examination of the seminal vesicle and prostate, a higher percentage of hyperplastic lesions were observed in both transgenic models compared to WT mice. (C) Immune infiltration graph indicating cell infiltration and inflammation phenotypes found in all transgenic mice and WT reproductive system samples. All of the images were captured using the Microscope Olympus BX-61. The p-value was obtained using a one-tailed student’s t-test (*p < 0.05), (**p < 0.01), and (***p < 0.001).The role of PIM1/PIM2 kinases in tumors of the male reproductive system.- Scientific Reports. Not Altered. CC.