Myofibroblastoma is a benign spindle cell tumor of mammary stroma composed of fibroblasts and myofibroblasts.

What is the Pathology of Myofibroblastoma?

The pathology of myofibroblastoma is:

-Etiology: The cause of myofibroblastoma is the pathogenetic role of hormones due to ER, PR and AR expression.

-Genes involved: Loss of 13q14 region, including RB1 and FOXO1 loci

-Pathogenesis: The sequence of events that lead to myofibroblastoma is the proliferation of CD34+ mammary stromal fibroblasts and myofibroblasts capable of multidirectional mesenchymal differentiation.

-Morphology: The morphology associated with myofibroblastoma shows a palpable breast mass.

-Histology: The histology associated with myofibroblastoma shows a well-circumscribed lesion that lacks a true capsule with bland, uniform, monotonous short to elongated spindle cells arranged as short haphazard intersecting fascicles admixed with bands of hyalinized collagen.

How does Myofibroblastoma Present?

Patients with myofibroblastoma may be male or female. The symptoms, features, and clinical findings associated with myofibroblastoma include a painless, nontender, slow growing, mobile breast mass.

How is Myofibroblastoma Diagnosed?

Myofibroblastoma is diagnosed by imaging which includes ultrasound, mammogram, and MRI. The invasive procedures include biopsy and fine needle aspiration (FNA).

How is Myofibroblastoma Treated?

Myofibroblastoma is treated by surgical excision.

What is the Prognosis of Myofibroblastoma?

The prognosis of myofibroblastoma is good.