Non-gonococcal urethritis, inflammation of the urethra, is the most common sexually transmitted illness in men. Urethritis can be infectious or non-infectious. 

What is the Pathology of Non-Gonococcal Urethritis?

The pathology of non-gonococcal urethritis is:

-Etiology: The most common cause of non-gonococcal urethritis is Chlamydia trachomatis, mycoplasma genitalium.

-Genes involved: None, non-gonococcal urethritis is an infectious disease.

-Pathogenesis: The sequence of events that lead to Non-gonococcal urethritis is chlamydia. C. trachomatis typically infects columnar epithelial cells at mucosal sites. It replicates in host cells eventually causing cell death.

-Morphology: The morphology associated with Non-gonococcal urethritis shows mucopurulent discharge.

-Histology: The histology associated with Non-gonococcal urethritis shows polymorphonuclear leukocytes without the presence of intracellular gram-negative diplococci on gram stain. 

How does Non-Gonococcal Urethritis Present?

Patients with non-gonococcal urethritis typically affect men in adolescence or adulthood. The symptoms, features, and clinical findings associated with non-gonococcal urethritis include pain or a burning sensation upon urination (dysuria), a white/cloudy discharge, and a feeling that one needs to pass urine frequently.

How is Non-Gonococcal Urethritis Diagnosed? 

Non-gonococcal urethritis is diagnosed through gram stain of the urethral discharge under a microscope.

How is Non-Gonococcal Urethritis Treated?

Non-gonococcal urethritis is treated with antibiotics. 

What is the Prognosis of Non-Gonococcal Urethritis?

The prognosis of non-gonococcal urethritis is good. It is generally a self-limited disease and resolves, even without therapy, with no complications in most cases.