What is NUT Midline Carcinoma?

NUT Midline Carcinoma
NUT Midline Carcinoma. Diagnosis of nuclear protein of the testis (NUT) midline carcinoma. A) Undifferentiated small cells with foci of squamous differentiation (Hematoxylin & Eosin, 20×). B) Immunohistochemistry of tumor cell nuclei showing speckled staining for NUT (250×) using anti-NUT rabbit polyclonal antibody (clone C52, 1:100). Usefulness of Nuclear Protein in Testis (NUT) Immunohistochemistry in the Cytodiagnosis of NUT Midline Carcinoma: A Brief Case Report. Sayapina MS, Savelov NA, Karseladze AI, Bulanov AA, Tryakin AA, Nosov DA, Garin AM,Tjulandin SA. - Rare Tumors. (2016). Not Altered. CC.

NUT Midline Carcinoma is an erratic and aggressive carcinoma categorized by chromosomal reorganization occurring most frequently in the mediastinum.

What is the Pathology of NUT Midline Carcinoma?

The pathology of NUT midline carcinoma is:

-Etiology: The cause of NUT midline carcinoma is believed to be gene rearrangement. 

-Genes involved: MYC, MED24, and p63 genes. 

-Pathogenesis: The sequence of events that lead to NUT midline carcinoma is not well understood as it is diagnosed at a late stage.

-Histology: The histology associated with NUT midline carcinoma shows an ill differentiated carcinoma which has a habit to be pleomorphic.

How does NUT Midline Carcinoma Present? 

Patients with NUT midline carcinoma typically have no substantial gender difference, present at age range of 5-15years. The symptoms, features, and clinical findings associated with NUT midline carcinoma include Cough, pain, fatigue, shortness of breath, and weight loss.

How is NUT Midline Carcinoma Diagnosed? 

NUT midline carcinoma is diagnosed by Laboratory studies: Testing a monoclonal antibody to NUT (C52B1) with immunohistochemical (IHC) nuclear staining. Imaging studies: Digital radiography, CT scans, and positron emission tomography.

How is NUT Midline Carcinoma Treated? 

NUT midline carcinoma is treated traditionally through radiotherapy and complete tumor resection through effective plans is still in research.

What is the Prognosis of NUT Midline Carcinoma?

The prognosis of NUT midline carcinoma is poor since it is diagnosed at a late stage, and no effective treatment is yet known.

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Last updated on May 16, 2022