What is Oncocytoma?

Oncocytoma
Oncocytoma. Representative images of the oncocytomas included in this study. A, Axial contrast-enhanced CT, axial SPECT (B), and axial SPECT/CT fusion images of a right upper pole oncocytoma (C) with a representative histologic image (D, hematoxylin and eosin stain [HE] ×20) (patient 1, white and black arrowheads). E, Axial contrast-enhanced T1-weighted MRI, axial SPECT (F), and axial SPECT/CT fusion images of a right medial interpolar oncocytoma (G) with an accompanying histologic image (H, HE ×20) (patient 2, white and black arrowheads). I, Coronal contrast-enhanced CT, coronal SPECT (J), and coronal SPECT/CT fusion images of a right lower pole oncocytoma (K) with a corresponding histologic image (L, HE ×20) (patient 3, white and black arrowheads). Initial experience using 99mTc-MIBI SPECT/CT for the differentiation of oncocytoma from renal cell carcinoma. Rowe SP, Gorin MA, Gordetsky J, Ball MW, Pierorazio PM, Higuchi T, Epstein JI, Allaf ME, Javadi MS - Clinical nuclear medicine (2015). Not Altered. CC.

Oncocytoma is rare benign tumors made up of oncocytes, epithelial cells and characterized by the lacking complex I enzyme activity of the oxidative phosphorylation system instigated by mitochondrial DNA (mtDNA) mutations.

What is the Pathology of Oncocytoma?

The pathology of oncocytoma is: 

-Etiology: The cause of oncocytoma is genetic changes.

-Genes CCND1.

-Pathogenesis: The sequence of events that lead to oncocytoma is unclear.

-Morphology: The morphology associated with oncocytoma shows tan color tumor.

-Histology: The histology associated with oncocytoma shows a plethora of mitochondria, finely granular eosinophilic cytoplasm.

How does Oncocytoma Present? 

Patients with oncocytoma are typically more common in males present at the age range of 60 years. The symptoms, features, and clinical findings associated with oncocytoma include hematuria, flank pain, and a palpable mass.

How is Oncocytoma Diagnosed? 

Oncocytoma is diagnosed by radiological imaging studies, and renal biopsy.

How is Oncocytoma Treated? 

Oncocytoma is treated conservatively with partial nephrectomy.

What is the Prognosis of Oncocytoma?

The prognosis of oncocytoma is good. The condition rarely metastasizes.

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Last updated on May 24, 2022