What is Retinoblastoma?

Retinoblastoma

(A,B) Hematoxylin and eosin staining confirm the presence of retinoblastoma cells, ×200, ×400, respectively. (C) In situ hybridization for human papilloma virus (HPV) in retinoblastoma tumor cells is negative for HPV-DNA. (D) Squamous cell carcinoma of the uterine cervix stain positive for HPV-DNA. Dark purple staining (depicted in black arrows) indicates integrated or episomal HPV-DNA.Human papilloma virus in retinoblastoma tissues from Korean patients. Ryoo NK, Kim JE, Choung HK, Kim N, Lee MJ, Khwarg SI - Korean journal of ophthalmology : KJO (2013). Not Altered. CC.

Retinoblastoma is eye cancer that originates from the retina.

What is the Pathology of Retinoblastoma?

The pathology of retinoblastoma is mutational inactivation of both alleles of RB1 gene mapping to chromosome 13q14 and encodes retinoblastoma protein acting as tumor suppressor.

How does Retinoblastoma Present?

Retinoblastoma typically presents in affected children with light induced white coloration of the pupil, different directional eye focus, redness, and swelling of the eye.

How is Retinoblastoma Diagnosed?

Retinoblastoma is diagnosed by eye examination, ultrasound image test, CT scan, MRI.

How is Retinoblastoma Treated?

Retinoblastoma is treated with intra-arterial chemotherapy, intravitreal chemotherapy, laser therapy, cryotherapy, radiation therapy, and surgery.

What is the Prognosis of Retinoblastoma?

The prognosis of retinoblastoma is fair.

Last updated on May 23, 2022