(a) H and E. The diffuse pattern of basophilic cells seen in the 2010 lesion is characteristic of corticotroph adenoma. There is mild nuclear pleomorphism. (b) ACTH stain shows positive cytoplasmic staining, confirming the diagnosis of corticotroph adenoma. (c) Ki-67, a proliferation marker, is increased to 5–7%. Chemotherapy-induced regression of an adrenocorticotropin-secreting pituitary carcinoma accompanied by secondary adrenal insufficiency: Cornell RF, Kelly DF, Bordo G, Carroll TB, Duong HT, Kim J, Takasumi Y, Thomas JP, Wong YL, Findling JW - Case reports in endocrinology (2013). Not altered. CC.
Secondary adrenocortical insufficiency is characterized by too little ACTH that can lead to too little of the glucocorticoids and androgens.
Examples of Secondary Adrenocortical Insufficiency include:
- Decreased ACTH due to CNS disorder
- Waterhouse-Friederichsen syndrome
