What is Shigellosis?

Shigellosis
The involvement of host membrane trafficking in Shigella vacuolar rupture. Shigella induces its uptake into a vacuole that gets surrounded by an actin cage. Concomitantly, vesicles around the bacteria are modulated by IpgD to deplete PI(4,5)P2 and form PI(5)P (highlighted in green). This change of lipid content leads to the recruitment of the Rab GTPases Rab5 and Rab11. Vesicles around the Shigella-containing vacuole make contact with the bacterial compartment. During these contacts, the vacuole ruptures through a mechanism that requires further characterization. Cytosolic Access of Intracellular Bacterial Pathogens: The Shigella Paradigm. Mellouk N, Enninga J - Frontiers in cellular and infection microbiology (2016). Not Altered. CC.

Shigellosis is an intestinal infection caused by a family of bacteria known as shigella.

What is the Pathology of Shigellosis?

The pathology of shigellosis is:

-Etiology: The cause of shigellosis is the Shigella bacteria

-Genes involved: None.

-Pathogenesis: The sequence of events that lead to shigellosis are: fewer than 100 bacterial cells can be enough to cause an infection. Shigella species generally invade the epithelial lining of the colon, causing severe inflammation and death of the cells lining the colon.

-Histology: The histology associated with shigellosis shows bacteria.

How does Shigellosis Present?

Patients with shigellosis typically all genders at all ages. The symptoms, features, and clinical findings associated with shigellosis include fever, bloody diarrhea, and cramps. 

How is Shigellosis Diagnosed?

Shigellosis is diagnosed by laboratory identification of Shigella in the stool poop of an ill person.

How is Shigellosis Treated?

Shigellosis is treated by ciprofloxacin and azithromycin which are recommended oral antibiotics.

What is the Prognosis of Shigellosis?

The prognosis of shigellosis is good. Most people with shigellosis feel better in 4–7 days, but may still be contagious for up to 2 weeks after they recover.