What is Solid-Pseudopapillary Neoplasm?

Solid-Pseudopapillary Neoplasm
Solid pseudopapillary neoplasm of pancreas in 28 year-old female.A. On axial contrast-enhanced CT image, low density mass (asterisk) with thick peripheral, rim calcification (arrowhead) is located in pancreatic tail. Main pancreatic duct is not dilated. B. On ultrasound scan, bulging contoured mass (asterisk) is suspected in pancreatic tail. Peripheral, rim calcification (arrowheads) of mass appears as hyperechogenicity with posterior acoustic presentation. Solid pseudopapillary neoplasm was diagnosed after distal pancreatectomy.Imaging Patterns of Intratumoral Calcification in the Abdominopelvic Cavity. Yu MH, Kim YJ, Park HS, Jung S, Jeon HJ.- Korean J Radiol.(2017). Not Altered. CC.

Solid-pseudopapillary neoplasms are rare tumors of the pancreas with malignant potential characterized by large, well-circumscribed masses having solid and cystic zones.

What is the Pathology of Solid-Pseudopapillary Neoplasm?

The pathology of solid-pseudopapillary neoplasm is:

-Etiology: The cause of solid-pseudopapillary neoplasm is unclear.

-Genes involved: Beta-catenin gene on exon 3.

-Pathogenesis: The sequence of events that lead to solid-pseudopapillary neoplasm is  unclear.

-Morphology: The morphology associated with solid-pseudopapillary neoplasm shows large, well-circumscribed masses partly solid and partly cyst filled with hemorrhagic debris.

-Histology: The histology associated with solid-pseudopapillary neoplasm shows cells grow in solid sheets.

How does Solid-Pseudopapillary Neoplasm Present? 

Patients with solid-pseudopapillary neoplasm typically common in females present at an age range of the 3rd decade. The symptoms, features, and clinical findings associated with solid-pseudopapillary neoplasm include abdominal discomfort, abdominal mass, jaundice.

How is Solid-Pseudopapillary Neoplasm Diagnosed? 

Solid-pseudopapillary neoplasm is diagnosed through clinical presentation and radiological studies- ultrasonography (US), CT scan, and magnetic resonance imaging (MRI).

How is Solid-Pseudopapillary Neoplasm Treated? 

Solid-pseudopapillary neoplasm is treated through complete resection.

What is the Prognosis of Solid-Pseudopapillary Neoplasm?

The prognosis of solid-pseudopapillary neoplasm is fair. They have malignant potential though timely resection and diagnosis offers long-term survival.