What is Transfusion Associated Graft Versus Host Disease?

Transfusion Associated Graft Versus Host Disease
Transfusion Associated Graft Versus Host Disease. Mononuclear cell infiltration and inflammation of affected epithelium, with focal vacuolation of basal epithelial cells, (H&E, ×60). Transfusion associated graft versus host disease in an immunocompetent individual following coronary artery bypass grafting. Nagendra GT, M N R, Hegde DP, Damodar S, Gupta R - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine (2008). Not Altered. CC.

Transfusion associated graft versus host disease is a reaction that occurs when transfusion of the bone marrow or other blood components is used is rejected by the host cells.

What is the Pathology of Transfusion Associated Graft Versus Host Disease?

The pathology of transfusion associated graft versus host disease is:

-Etiology: The cause of transfusion associated graft versus host is idiopathic.

-Genes involved: NA.

-Pathogenesis: The sequence of events that lead to transfusion associated graft versus host disease occurs when the donated components in the body of the host are viewed as foreign, and they begin to be attacked by the host cells.

-Morphology: NA.

-Histology: NA.

How does Transfusion Associated Graft Versus Host Disease Present? 

Patients with transfusion associated graft versus host disease typically more in male present at age range of the elderly. The symptoms, features, and clinical findings associated with transfusion associated graft versus host disease include fever, rash, diarrhea, bone marrow suppression, hepatitis, pruritic and painful rash.

How is Transfusion Associated Graft Versus Host Disease Diagnosed? 

Transfusion associated graft versus host disease is diagnosed physical examination, complete blood count, liver function tests, Schirmer test, barium swallow meal.   

How is Transfusion Associated Graft Versus Host Disease Treated? 

Transfusion associated graft versus host disease is treated by immunosuppressors.  

What is the Prognosis of Transfusion Associated Graft Versus Host Disease?

The prognosis of transfusion associated graft versus host disease poor since it is very fatal.