Heart Failure Pathology Study Guide

Congestive Heart Failure
Congestive Heart Failure. Ultrasound showing severe systolic heart failure. Ben Smith. Not altered. CC BY-SA 4.0

Heart Failure Pathology Video

Congestive Heart Failure (CHF)

Congestive heart failure is pump failure of the heart.

Congestive heart failure is divided into:

  • Left sided heart failure
  • Right sided heart failure
  • Congestive Heart Failure
    Congestive Heart Failure. Ultrasound showing severe systolic heart failure. Ben Smith. Not altered. CC BY-SA 4.0

Left-Sided Heart Failure

Risk factors for left sided heart failure include:

  • Myocardial infarction
  • Ischemia
  • Hypertension
  • Dilated cardiomyopathy
  • Restrictive cardiomyopathy

Clinical features of left sided heart failure include:

  • Pulmonary congestion
  • Dyspnea
  • Paroxysmal nocturnal dyspnea (because of increased venous return when lying flat)
  • Orthopnea
  • Cyanosis

Small, congested capillaries can burst, resulting in intra alveolar hemorrhage.

Left sided heart failure histology shows marked by hemosiderin-laden macrophages (‘heart-failure’ cells).

Reduced flow to kidneys results in activation of the renin-angiotensin system.

Fluid retention exacerbates congestive heart failure.

ACE inhibitor therapy is the mainstay of treatment.

  • Burger and fries hypertension athereosclerosis
    Burger and fries hypertension athereosclerosis. Christopher Williams. Not altered. CC.

Right-Sided Heart Failure

Causes of right sided heart failure include:

  • Left sided heart failure (most common reason)
  • Chronic lung disease
  • Left-to-right shunt

Clinical features of right sided heart failure are secondary to congestion, and include:

  • Edema
  • Jugular venous distension
  • Hepatosplenomegaly