Large Granular Lymphocytic Leukemia

What is Large Granular Lymphocytic Leukemia?

Large granular lymphocytic leukemia  is a chronic T cell lymphoproliferative disorder characterized by a clonal proliferation of mature cytotoxic T cells. What is the Pathology of Large Granular Lymphocytic Leukemia? The pathology of large granular lymphocytic leukemia is: -Etiology: The…
T-Cell Prolymphocytic Leukemia_Histology

What is T-Cell Prolymphocytic Leukemia? 

T-cell prolymphocytic leukemia is an aggressive T cell leukemia comprised of small to medium sized mature T cells with high white blood cell count and widespread organ involvement. What is the Pathology of T-Cell Prolymphocytic Leukemia? The pathology of t-cell…
Peripheral T-Cell Neoplasms_Histology

What are Peripheral T-Cell Neoplasms?

Peripheral T-Cell Neoplasms are a group of aggressive lymphomas that develop from mature-stage white blood cells, T cells and NK cells.  Examples of Peripheral T-Cell Neoplasms include:  T-cell prolymphocytic leukemia Large granular lymphocytic leukemia Mycosis fungoidesSézary syndrome Anaplastic large-cell lymphoma Angioimmunoblastic T-cell lymphoma Enteropathy-associated T-cell…
Multiple Myeloma

What is a Plasmacytoma?

Plasmacytoma is a tumor of plasma cells of bony or soft tissue and can occur anywhere in the body without evidence of systemic disease.  What is the Pathology of Plasmacytoma? The pathology of plasmacytoma is: -Etiology: The cause of plasmacytoma…
AL Amyloidosis

What is Primary or Immunocyte-Associated Amyloidosis?

Primary or immunocyte-associated amyloidosis is a type of amyloidosis that is immunocyte-derived and associated with elevated immunoglobulin free light chains in serum produced by monoclonal plasma cells. What is the Pathology of Primary or Immunocyte-Associated Amyloidosis? The pathology of primary…
Heavy Chain Disease

What is Heavy Chain Disease?

Heavy chain disease is a B-cell proliferative disorder characterized by production of abnormal, structurally incomplete, immunoglobulin heavy chains without the corresponding light chains. What is the Pathology of Heavy Chain Disease? The pathology of heavy chain disease is: -Etiology: The…
Waldenstrom Macroglobulinemia

What is Waldenstrom Macroglobulinemia?

Waldenstrom macroglobulinemia is a type of non-Hodgkin lymphoma (NHL). The neoplastic cells make large amounts of an abnormal protein (called a macroglobulin). Another name for WM is lymphoplasmacytic lymphoma. What is the Pathology of Waldenstrom Macroglobulinemia? The pathology of Waldenstrom…
MGUS SPEP

What is MGUS?

MGUS is monoclonal gammopathy of unknown significance. MGUS involves the production of M-protein by benign plasma cells. What is the Pathology of MGUS? The pathology of MGUS is: -Etiology: The cause of MGUS is not known. Infection, immune system issues,…
Multiple Myeloma

What is Multiple Myeloma?

Multiple myeloma is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. What is the Pathology of…
Plasmacytoma

What are Plasma Cell Neoplasms? 

Plasma cell neoplasms are diseases in which the body makes too many plasma cells. Plasma cells develop from B lymphocytes (B cells), a type of white blood cell that is made in the bone marrow.   Examples of plasma cell neoplasms…