Primary Myelofibrosis

What is Primary Myelofibrosis?

Primary myelofibrosis is a rare bone marrow disorder characterized by abnormalities in blood cell production (hematopoiesis) and scarring (formation of fibrous tissue) within the bone marrow. What is the Pathology of Primary Myelofibrosis? The pathology of primary myelofibrosis is: -Etiology:…
Essential Thrombocythemia

What is Essential Thrombocythemia?

Essential thrombocythemia is a blood disorder in which the bone marrow produces too many platelets. What is the Pathology of Essential Thrombocythemia? The pathology of essential thrombocythemia is: -Etiology: The cause of essential thrombocythemia is acquiring (not inheriting) a somatic…
Polycythemia Vera

What is Polycythemia Vera?

Polycythemia vera is a blood disorder that involves an overproduction of blood cells in the bone marrow (myeloproliferation). The overproduction of red blood cells is most dramatic, but the production of white blood cells and platelets are also elevated in…
Chronic Myelogenous Leukemia Karyotype

What is Chronic Myelogenous Leukemia?

Chronic myelogenous leukemia is a myeloproliferative disorder characterized by increased proliferation of granulocytic cell line and determined to have the Philadelphia chromosome/translocation t(9;22)(q34;q11.2). What is the Pathology of Chronic Myelogenous Leukemia? The pathology of chronic myelogenous leukemia is: -Etiology: The…
Myeloproliferative Disorders

What are Myeloproliferative Disorders?

Myeloproliferative disorders are a group of hematopoietic stem cell disorders characterized by an abnormal proliferation of one or more hematologic cell lines (platelets, white blood cells and red blood cells). Examples of myeloproliferative disorders include:  Chronic myelogenous leukemiaPolycythemia veraEssential thrombocythemiaPrimary…
Myelodysplastic Syndromes

What are Myelodysplastic Syndromes?

Myelodysplastic syndromes are a group of cancers in which immature blood cells in the bone marrow do not develop into mature blood cells. These cells stay within the bone marrow in an immature state.  “Myelodysplastic” come from “myelo” which means…
Acute Myeloid Leukemia

What is Acute Myeloid Leukemia?

Acute myeloid leukemia is a tumor of hematopoietic progenitors caused by acquired oncogenic mutations that impede differentiation, leading to the accumulation of immature myeloid blasts in the marrow. What is the Pathology of Acute Myeloid Leukemia? The pathology of acute…
Myeloid Neoplasms

What are Myeloid Neoplasms?

Myeloid neoplasms are tumors that arise from early hematopoietic progenitors. Examples of myeloid neoplasms include: Acute myeloid leukemiaMyelodysplastic syndromesMyeloproliferative disorders
Hemophagocytic Lymphohistiocytosis

What is Hemophagocytic Lymphohistiocytosis?

Hemophagocytic lymphohistiocytosis is a rare hematologic disorder characterized by an uncontrolled immune response with organ infiltration of lymphocytes and histiocytes, and organ damage caused by excessive production of pro-inflammatory cytokines.