Von Hippel-Lindau Disease

What is Von Hippel-Lindau Disease?

Von Hippel-Lindau disease is an inherited disorder characterized by the formation of tumors and fluid-filled sacs (cysts) in many different parts of the body. These tumors may be either noncancerous or cancerous and most frequently appear during young adulthood. What…
Tuberous Sclerosis

What is Tuberous Sclerosis?

Tuberous sclerosis is a rare genetic multisystem disorder with a wide range of potential signs and symptoms and is associated with the formation of benign tumors. What is the Pathology of Tuberous sclerosis? Etiology: The cause of Tuberous sclerosis is…
Familial Tumor Syndromes

What are Familial Tumor Syndromes?

Familial tumor syndromes are genetic disorders in which inherited genetic mutations in one or more genes predispose the affected individuals to the development of certain cancers,  Examples of familial tumor syndromes include: Tuberous sclerosisVon Hippel-Lindau disease Neurofibromatosis
Meningiomas

What are Meningiomas?

Meningiomas are the most common type of primary brain tumors. These tumors originate in the meninges, which are the outer three layers of tissue between the skull and the brain that cover and protect the brain just under the skull.…
Pineal Parenchymal Tumors

What is a Pineal Parenchymal Tumors?

A pineal parenchymal tumor is a primary central nervous system (CNS) tumor. These tumors begin in the brain (in the pineal gland) but can spread to the spinal cord. What is the Pathology of Pineal Parenchymal Tumors? Etiology: The cause…
Germ Cell Tumors

What are Germ Cell Tumors?

A germ cell tumor is a neoplasm derived from germ cells which may be benign or malignant.  What is the Pathology of Germ Cell Tumors? Etiology: The cause of Germ Cell Tumors is unknown. Genes involved: Unknown.  Pathogenesis: Proliferation of…
Primary CNS Lymphoma

What is a Primary CNS Lymphoma?

A primary CNS lymphoma is a rare form of extranodal non-Hodgkin lymphoma that is typically confined to the brain, eyes, and cerebrospinal fluid without evidence of systemic spread. What is the Pathology of Primary CNS Lymphoma? Etiology: The cause of…
Atypical Rhabdoid Tumor

What is an Atypical Rhabdoid Tumor?

An Atypical Rhabdoid /Teratoid Tumor is a rare, fast-growing tumor of the brain and spinal cord. Atypical rhabdoid tumor usually occurs in children aged three years and younger, although it can occur in older children and adults. About half of…
Medulloblastoma

What is a Medulloblastoma?

A medulloblastoma is a common type of brain tumor. What is the Pathology of Medulloblastoma? Etiology: The cause of Medulloblastoma is not known. Genes involved: PTCH2 on chromosome 1p32, CTNNB1 on chromosome 3p, and APC on chromosome 5q. Pathogenesis: The…